A digital imaging photometry system for cometary data acquisition

This report describes a digital imaging photometry system developed in the Space Science Laboratory at the Marshall Space Flight center. The photometric system used for cometary data acquisition is based on an intensified secondary electron conduction (ISEC) vidicon coupled to a versatile data acquisition system which allows real-time interactive operation. Field tests on the Orion and Rosette nebulas indicate a limiting magnitude of approximately m sub v = 14 over the 40 arcmin field-of-view. Observations were conducted of Comet Giacobini-Zinner in August 1985. The resulting data are discussed in relation to the capabilities of the digital analysis system. The development program concluded on August 31, 1985

Metabolomic study of the LDL receptor null mouse fed a high-fat diet reveals profound perturbations in choline metabolism that are shared with ApoE null mice

Failure to express or expression of dysfunctional low-density lipoprotein receptors (LDLR) causes familial hypercholesterolemia in humans, a disease characterized by elevated blood cholesterol concentrations, xanthomas, and coronary heart disease, providing compelling evidence that high blood cholesterol concentrations cause atherosclerosis. In this study, we used 1H nuclear magnetic resonance spectroscopy to examine the metabolic profiles of plasma and urine from the LDLR knockout mice. Consistent with previous studies, these mice developed hypercholesterolemia and atherosclerosis when fed a high-fat/cholesterol/cholate-containing diet. In addition, multivariate statistical analysis of the metabolomic data highlighted significant differences in tricarboxylic acid cycle and fatty acid metabolism, as a result of high-fat/cholesterol diet feeding. Our metabolomic study also demonstrates that the effect of high-fat/cholesterol/cholate diet, LDLR gene deficiency, and the diet-genotype interaction caused a significant perturbation in choline metabolism, notably the choline oxidation pathway. Specifically, the loss in the LDLR caused a marked reduction in the urinary excretion of betaine and dimethylglycine, especially when the mice are fed a high-fat/cholesterol/cholate diet. Furthermore, as we demonstrate that these metabolic changes are comparable with those detected in ApoE knockout mice fed the same high-fat/cholesterol/cholate diet they may be useful for monitoring the onset of atherosclerosis across animal models

Optical image of a cometary nucleus: 1980 flyby of Comet Encke

The feasibility was investigated of obtaining optical images of a cometary nucleus via a flyby of Comet Encke. A physical model of the dust cloud surrounding the nucleus was developed by using available physical data and theoretical knowledge of cometary physics. Using this model and a Mie scattering code, calculations were made of the absolute surface brightness of the dust in the line of sight of the on-board camera and the relative surface brightness of the dust compared to the nucleus. The brightness was calculated as a function of heliocentric distance and for different phase angles (sun-comet-spacecraft angle)

Identifying Trippers and Non-Trippers Based on Knee Kinematics During Obstacle-Free Walking

Trips are a major cause of falls. Sagittal-plane kinematics affect clearance between the foot and obstacles, however, it is unclear which kinematic measures during obstacle-free walking are associated with avoiding a trip when encountering an obstacle. The purpose of this study was to determine kinematic factors during obstacle-free walking that are related to obstacle avoidance ability. It was expected that successful obstacle avoidance would be associated with greater peak flexion/dorsiflexion and range of motion (ROM), and differences in timing of peak flexion/dorsiflexion during swing of obstacle-free walking for the hip, knee and ankle. Three-dimensional kinematics were recorded as 35 participants (young adults age 18–45 (N = 10), older adults age 65+ without a history of falls (N = 10), older adults age 65+ who had fallen in the last six months (N = 10), and individuals who had experienced a stroke more than six months earlier (N = 5)) walked on a treadmill, under obstacle-free walking conditions with kinematic features calculated for each stride. A separate obstacle avoidance task identified trippers (multiple obstacle contact) and non-trippers. Linear discriminant analysis with sequential feature selection classified trippers and non-trippers based on kinematics during obstacle-free walking. Differences in classification performance and selected features (knee ROM and timing of peak knee flexion during swing) were evaluated between trippers and non-trippers. Non-trippers had greater knee ROM (P = .001). There was no significant difference in classification performance (P = .193). Individuals with reduced knee ROM during obstacle-free walking may have greater difficulty avoiding obstacles

Experiment Luxembourg, Scientific Report No. 4

Experiment Luxembourg was designed to measure the electron density and electron collision-frequency as a function of height in the D region over College, Alaska using the technique of radio-wave interaction. A block diagram, which includes all the equipment necessary for the actual operation of the experiment, is described and illustrated in detail. The major parts of the system are: the disturbing transmitter operating on 17.5 Mc/s and using a 4x4 array of Yagi antennas, the wanted transmitter operating on ~ 5 Mc/s and using a circular polarization unit with 4 dipoles arranged in a quadrangle, a similar circular polarization unit and antenna for 5 Mc/s at the receiving site, and the delicate receiving system which detects a cross-modulation of 1x10 -4 for a one volt input signal. Some values of electron density and collision-frequency have been obtained and will be discussed in following publications.Contract No. AF 19(604)-3880 -- GEOPHYSICS RESEARCH DIRECTORATE AIR FORCE CAMBRIDGE RESEARCH LABORATORIES AIR FORCE RESEARCH DIVISION (ARDC) UNITED STATES AIR FORCE BEDFORD, MASSACHUSETTSLIST OP FIGURES -- ABSTRACT -- INTRODUCTION -- TRANSMITTING SITE : Timer Wanted transmitter ; Circular polarization unit ; 5 Mc/s antenna ; Disturbing transmitter ; Duplexer ; 17.5 Mc/s receiver ; 17.5 Mc/s antenna -- RECEIVING SITE : 5 Mc/s antenna ; Circular polarization unit ; 5 Mc/s Super-pro receiver ; Wide band IF amplifier ; Pulse shaper and delay control ; Receiver gate and reference signal generator ; Signal gate ; Selective amplifier ; Phase sensitive detector ; E.A. recorder ; 17.5 Mc/s Collins receiver ; Scope unit ; Calibration -- Results -- AcknowledgementsYe

Driver Accelerator Design for the 10 kW Upgrade of the Jefferson Lab IR FEL

An upgrade of the Jefferson Lab IR FEL is now under construction. It will provide 10 kW output light power in a wavelength range of 2-10 microns. The FEL will be driven by a modest-sized 80-210 MeV, 10 mA energy-recovering superconducting RF (SRF) linac. Stringent phase space requirements at the wiggler, low beam energy, and high beam current subject the design to numerous constraints. These are imposed by the need for both transverse and longitudinal phase space management, the potential impact of collective phenomena (space charge, wakefields, beam break-up (BBU), and coherent synchrotron radiation (CSR)), and interactions between the FEL and the accelerator RF system. This report addresses these issues and presents an accelerator design solution meeting the requirements imposed by physical phenomena and operational necessities.Comment: submission THC03 for LINAC200

Gaussian approximations for stochastic systems with delay: chemical Langevin equation and application to a Brusselator system

We present a heuristic derivation of Gaussian approximations for stochastic chemical reaction systems with distributed delay. In particular we derive the corresponding chemical Langevin equation. Due to the non-Markovian character of the underlying dynamics these equations are integro-differential equations, and the noise in the Gaussian approximation is coloured. Following on from the chemical Langevin equation a further reduction leads to the linear-noise approximation. We apply the formalism to a delay variant of the celebrated Brusselator model, and show how it can be used to characterise noise-driven quasi-cycles, as well as noise-triggered spiking. We find surprisingly intricate dependence of the typical frequency of quasi-cycles on the delay period.Comment: 14 pages, 9 figure

Comparing Ecological Sensitivity with Stream Flow Rates in the Apalachicola-Chattahoochee-Flint River Basin

Environmental Economics and Policy, Resource /Energy Economics and Policy,

Regional agriculture surveys using ERTS-1 data

The Center for Remote Sensing Research has conducted studies designed to evaluate the potential application of ERTS data in performing agricultural inventories, and to develop efficient methods of data handling and analysis useful in the operational context for performing large area surveys. This work has resulted in the development of an integrated system utilizing both human and computer analysis of ground, aerial, and space imagery, which has been shown to be very efficient for regional crop acreage inventories. The technique involves: (1) the delineation of ERTS images into relatively homogeneous strata by human interpreters, (2) the point-by-point classification of the area within each strata on the basis of crop type using a human/machine interactive digital image processing system; and (3) a multistage sampling procedure for the collection of supporting aerial and ground data used in the adjustment and verification of the classification results

Mapping lung cancer epithelial-mesenchymal transition states and trajectories with single-cell resolution.

Elucidating the spectrum of epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) states in clinical samples promises insights on cancer progression and drug resistance. Using mass cytometry time-course analysis, we resolve lung cancer EMT states through TGFβ-treatment and identify, through TGFβ-withdrawal, a distinct MET state. We demonstrate significant differences between EMT and MET trajectories using a computational tool (TRACER) for reconstructing trajectories between cell states. In addition, we construct a lung cancer reference map of EMT and MET states referred to as the EMT-MET PHENOtypic STAte MaP (PHENOSTAMP). Using a neural net algorithm, we project clinical samples onto the EMT-MET PHENOSTAMP to characterize their phenotypic profile with single-cell resolution in terms of our in vitro EMT-MET analysis. In summary, we provide a framework to phenotypically characterize clinical samples in the context of in vitro EMT-MET findings which could help assess clinical relevance of EMT in cancer in future studies